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KMID : 0604520130390040289
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 4 p.289 ~ p.294
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Whitening Effect of Biochanin A
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Park Sung-Ha
Kim A-Hyun
Park Byoung-Jun
Kim Jin-Jun
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Abstract
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To develop a new whitening agent for cosmetics, we investigated the inhibitory effects of biochanin A onmelanogenesis. The biochanoin A is an active component in the extracts of Dalbergia odorifera T. Chen. It reducedmelanin contents of B16F1 melanoma cells in a dose-dependent manner and decreased to about 48% at a concentration10 μg/mL. It also inhibited the expression in microphthalmia associated transcription factor (MITF), Tyrosinase,Tyrosinase related protein 1 (Trp-1), and Tyrosinase related protein 2 (Trp-2) in melanocytes. The results suggestedthat biochanin A has considerable potential as a cosmetics ingredient with a whitening effect.
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KEYWORD
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Biochanin A, whitening, melanin, Dalbergia odorifera T.CHEN
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